| abstract |
The invention relates to oxazole and thiazole derivatives with the general formula In wherein nX is O or S; nR¹ is halogen, CF₃, CN, NO₂, OH or C₁-C₆ alkoxy; nR² is hydrogen, C₁-C₆ alkyl, aryl, C₇-C₁₃ aralkyl, or an unsubstituted or substituted amino group, which may be part of a 5- or 6-membered ring; nR³ is C₁-C₆ hydrocarbon, C₇-C₁₃ aralkyl, or C₁-C₁₃ acyl; nand their pharmaceutically acceptable acid addition salts. n These new compounds have α₂-antagonist activity without dopamine activity and as such are specifically useful for the treatment of depression and other related illnesses, e.g. for treating patients with anxiety disorders and cognitive disturbances. |