| abstract |
The present invention concerns a pharmaceutical or cosmetical composition comprising an inert carrier, an effective amount of retinoic acid or a derivative thereof, or a stereochemically isomeric form thereof and an effective amount of a compound of formula <CHEM> an acid addition salt thereof or a stereochemically isomeric form thereof. The use for the manufacture for treating subjects suffering from disorders which are characterized by an increased proliferation and/or abnormal differentation of normal, preneoplastic or neoplastic epithelial cells the growth of which is sensitive to the action of retinoids is also disclosed. |