| titleOfInvention |
3,5-Di-tertiary-butyl-4-hydroxyphenyl-1,3,4-thiadiazoles, and oxadiazoles and 3,5-di-tertiary-butyl-4-hydroxiphenyl- 1,2,4-thiadiazoles, -oxadiazoles as antiinflammatory agents |
| abstract |
The present invention is novel compounds which nare 3,5-di-tertiary-butyl-4-hydroxyphenyl substituted n1,2,4- and 1,3,4-thiadazoles and oxadiazoles, and n1,2,4-triazoles, and pharmaceutically acceptable nadditions and base salts thereof, pharmaceutical ncompositions and methods of use therefor. The ninvention compounds are now found to have activity as ninhibitors of 5-lipoxygenase and/or cyclooxygenase nproviding treatment of conditions advantageously naffected by such inhibition including inflammation, narthritis, pain, fever, and the like. |