| abstract |
Peptides of formula I. ABCEFK- (D) -Tic-GMF′-I (I) where A is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulfonyl, cycloalkyl, aryl, arylsulfonyl, heteroaryl or an amino acid, which may be substituted, B is a basic amino acid, C is a di- or tripeptide, E is the rest of one aromatic amino acid, F independently of one another denotes an amino acid which is optionally substituted in the side chain or a direct bond, G is an amino acid, F 'as F is defined, can mean -NH- (CH₂) ₂₋₈ or optionally a direct bond, I -OH, -NH₂ or -NHC₂H₅ and K is a radical -NH- (CH₂) ₁₋₄-CO- or stands for a direct bond, have bradykinin antagonistic effect. Their therapeutic benefit includes all pathological conditions mediated, triggered or supported by bradykinin and bradykinin related peptides. The peptides of the formula I are produced by known methods of peptide synthesis. |