| abstract |
The invention relates to 1-B-4-phosphonylmethoxycyclopentane compounds having Formula I or Formula IIn wherein nR¹ and R² nare independently hydrogen, hydroxy, chlorine, bromine, or an organic substituent having 1 to 5 carbon atoms and selected from carbacyloxy, alkoxy, alkylthio, amino, alkylamino and dialkylamino, nR³ and R⁴ nare independently hydrogen, or organic phosphonic ester substituents having 1 to 12 carbon atoms and selected from alkyl, alkenyl, aryl, and aralkyl, nB is a heterocyclic group having at least one nitrogen heteroatom and up to three additional heteroatoms selected from nitrogen, oxygen and sulfur, said heterocyclic group being attached through a nitrogen heteroatom thereof, nand the pharmaceutically acceptable acid addition, metal, and amine salts thereof. n These compounds are useful for treating viral diseases and diseases of microbial origin. They are also effective against infections conditions and tumors. |