| abstract |
Cytostatically active cis-platinum derivatives which correspond to the following general formula I <IMAGE>, in which R¹ C1-C6-alkyl or C1-C4-alkyloxymethyl R² C1-C4-alkyl or C1-C4-alkyloxyethyl R¹ and R² together form a ketal -forming group -CH2-O-CR <4> (R <5>) - with R <4> H or CH3 and R <5> CH3 or phenyl and R³ an anion of cyclopropane-1,1-dicarboxylic acid, glycolic acid, Alpha-C1-C4-alkyl glycolic acid, C1-C4-alkyloxymalonic acid, mesoxalic acid, morpholin-4-yl-malonic acid or di- (C1-C4-alkyl) -amino-malonic acid and n are 0, 1 or 2, and methods for their Manufacture and its use as a medicine. |