| abstract |
Antimicrobial fluoroquinolonyl cephems of the formula: <CHEM> wherein (1) R<1> and R<2> are groups among those known in the art for substitution at the 7-position of an antimicrobially-active cephem; (2) R<3> is a substituted or unsubstituted, nitrogen-containing, heterocyclic moiety; and (3) R<4> is hydrogen, halogen, lower alkoxy or cyclic alkoxy, amino, nitro or cyano. Preferably, R<3> is substituted or unsubstituted piperazine, 3-aminopyrrolidine, or 3-aminomethylpyrrolidine. R<4> is preferably hydrogen or halogen. |