| abstract |
2,5,6,7-Tetranor-4,8-inter-m-phenylene PGl 2 derivatives such as 16-methyl-2,5,6,-tetranor-4,8-!nter-m-phenylene PGl 2 and its methyl ester, 17-methyl-2,5,6,7-tetranor-4,8-inter-m-phenylene PGl 2 and its methyl ester, 15-phenyl-2,5,6,7,16,17,18,19,20-nonanor-4,8-inter-m-phenylene PGI 2 , 16-methyl-17-phenyl-2,5,6,7,18,19,20-heptanor-4,8-l-nter-m- phenylene PGl 2 , 16,16-dimethyl-17-phenyl-2,5,6,7,18,19,20-heptanor--4,8-inter-m-phenylene PG1 2 , 16-methyl-16-phenoxy-2.5,6,7,17,18,19,20-octanor-4, 8- ,inter-m-phenylene PGI 2 , 16-methyl-16-phenoxy-2,5,6,7,18,19,20-heptanor-4,8--inter-m- phenylene PGl 2 and its methyl ester and 3-decarboxy-3-hydroxymethyl-16-methyl-16-phenoxy-2,5.6.7,18,19,20-heptanor- 4,8-inter-m-phenylene PG1 2 , useful as medicines, are disclosed. These derivatives are useful as, for example, antiulceric agents, hypotensives, and antithrombotic agents. |