| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21069
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6459 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46 |
| filingDate |
1988-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a385ad32406c22acec7f71504d15217
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c922bd885c3a0214b41e9b522c93136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5eb2e4aef98f5f25578147024b71fd0d |
| publicationDate |
1990-05-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0365597-A1 |
| titleOfInvention |
IMPROVED METHODS FOR THE TREATMENT OF VASCULAR DISEASES. |
| abstract |
Improved methods for preparing variants of human t-PA (tissue plasminogen activator) proteins with pharmacokinetic properties compared to natural t-PA. An illustration of such a variant, free of amino acids corresponding to amino acids ranging from 1 to 44 of t-PA, shows a half life of plasma greater than about 15 times half life of plasma of natural t-PA , as well as an elimination rate less than about 1/10 of the elimination rate of natural t-PA. Also disclosed are improved methods for treating vascular diseases using pharmaceutical compositions containing therapeutically effective amounts of said t-PA variants with pharmaceutically acceptable diluents or excipients. |
| priorityDate |
1987-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |