| abstract |
Analogs of 2-aryl-5-3-Methoxy-5-(2-hydroxynpropylsulfonyl)-4-propoxyphenyl)tetrahydrothiophene nwere prepared. n These compounds are found to be leukotriene ninhibitors and potent and specific PAF (Platelet nActivating Factor) antagonists. They are therefore nuseful in the treatment of various diseases or ndisorders mediated by the leukotriene and/or PAF, for nexample, inflammation, cardiovascular disorder, nasthma, lung edema, adult respiratory distress nsyndrome, pain, and aggregation of platelets. |