| abstract |
PCT No. PCT/CH89/00036 Sec. 371 Date Nov. 20, 1989 Sec. 102(e) Date Nov. 20, 1989 PCT Filed Feb. 24, 1989 PCT Pub. No. WO89/09215 PCT Pub. Date Oct. 5, 1989.The invention is concerned with the preparation of 2-[4-(3-oxo- cyclohexyl)phenyl] propionic acid and of its derivatives. This preparation consists in transforming 4-(3,3-ethylenedioxo- cyclohexyl) acetophenone or its derivatives of the general formula: <IMAGE> (IV) in which A1 represents a group <IMAGE> and B represents a group <IMAGE> and R1, R2, R3, R4, R5, which can be identical or different, represent each a hydrogen or an alkyl group into the desired compound of the general formula: <IMAGE> (I) in which A4 represents a group <IMAGE> This method offers the advantage of being easier to implement on an industrial scale and of having a better yield than the methods of preparation of the compounds of formula (I) according to prior art. |