| abstract |
Here is described the complete sequence of amino acids and nucleotides for the stimulating factor adenylate cyclase (ACSF), which facilitates the synthesis of ACSF in a culture of recombinant cells. Variants of the ACSF amino acid sequence and ACSF antibodies that are useful in the treatment of malignant humoral hypercalcemia or in immunological analyzes of ACSF are also described. In particular, antibodies capable of binding only to the C-terminal areas of ACSF are useful in immunological analyzes of ACSF, avoiding interference by parathyroid hormone. Also described are new polypeptides selected from the group of the basic peptide of ACSF, the C-terminus peptide of ACSF, or the ACSF domain containing both the basic peptide and the termination peptide vs. |