| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56ee5285e8e8edccb061046ff20da7a6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21069
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6459
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 |
| filingDate |
1989-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4db6a2b76ca20388667b349dd4c0ec6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b38b6ab4ce1f7f66f2d541d9d810d95
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2003ada97a927163190e77bea0f2cb3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2046319458a716a01764f549d73b5257 |
| publicationDate |
1990-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0361475-A1 |
| titleOfInvention |
Preparation of a plasminogen activator expressed in procaryotic cells |
| abstract |
A preparation of recombinant p-t-PA expressed in prokaryotes has an active p-t-PA content of more than 90% and a specific activity of more than 0.4 x 10⁶ IU / mg. To prepare such a preparation of recombinant p-t-PA expressed in prokaryotes by disrupting the expressing prokaryote cells, solubilizing under denaturing and reducing conditions and reactivating under oxidizing conditions, the reactivation mixture is concentrated and then purified by affinity chromatography. A p-t-PA preparation according to the invention can be used to dissolve blood clots. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0495398-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009063503-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6027888-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103852527-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103852527-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9747735-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009063503-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0559632-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5965424-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0559632-A2 |
| priorityDate |
1988-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |