| abstract |
This granular material consists of a porous granular support, carrying negative or positive charges, coated on its surface with a first impregnation layer of a hydrophilic polymer, carrying charges opposite to those of the support, the amount of said charges present. on said polymer being substantially equal to that of the charges present on the surface of the support; and another layer, fixed to the first by irreversible chemical coupling, of another hydrophilic, functional polymer, namely carrying functions conferring on said functional hydrophilic polymer a specific but reversible affinity for at least one biological substance. Among the applications of this material are the separation and purification of antithrombin III and coagulation factors (factors II, VII, VIII, IX, X), and the separation of activated coagulation factors (activated factors II). , IX activated, X activated), in solutions containing said non-activated factors. |