| abstract |
Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structuren wherein Q isn or a bond; nn is 1 to 4; X is O, -NH- or -NR⁴-; nR, R¹ and R 1a are the same or different and are H, lower alkyl, lower alkenyl, or a metal ion; nR² and R³ may be the same or different and are H or halogen; and nR⁴ is lower alkyl; nwith the proviso that when X is oxygen, n is 2, 3, or 4. n A method for using such compounds to inhibit cholesterol biosynthesis is also provided. |