| abstract |
Non-peptidyl compounds characterized generally as poly(aminoalkyl)aminocarbonyl aminoacyl aminodiol derivitives of amino acids are useful as resin inhibitors for the treatment of hypertension. Compounds of particular interest are of the formulan wherein X is selected from oxygen atom and methylene; wherein each of R 9 and R io is independently selected from hydrido, ethyl and methyl; wherein Rg and R 10 may be taken together to form a heterocyclic ring having five or six ring atoms and containing one or two nitrogen atoms as ring atoms; wherein each of R, and R 2 is independently selected from hydrido, methyl, ethyl and isopropyl; wherein R 3 is selected from benzyl, phenethyl, pyridylmethyl and 2-pyridylethyl; wherein each of R 4 and R 6 is hydrido; wherein R 7 is cyclohexylmethyl; wherein R 8 is selected fromn with the carbon bearing the hydroxyl radical being in the S configuration; wherein R 16 is selected from isopropyl, n-propyl, n-butyl and isobutyl; wherein each of R 11 , R 12 , R 14 and R, s is hydrido; wherein m is zero or one and each of n and p is a number independently selected from zero through three; or a pharmaceutically-acceptable salt thereof; with the proviso that where m is zero, then R s is selected from imidazolemethyl, thiazolemethyl and isobutyl; and with the further proviso that when m is one, then R s is methyl or ethyl. |