| abstract |
Described is a homogeneously modified protein, comprising one or more selected lysine residues occurring naturally, replaced by an appropriate amino acid, or comprising one or more lysine residues substituted in order to obtain other amino acids or introduced into a polypeptide sequence, leaving selected lysine residues having amino epsilon groups in the protein, and coupling amine-reactive compounds to lysine residues. Also disclosed are methods of producing the selected homogeneously modified proteins, as well as pharmaceutical compositions containing such proteins. |