http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0351399-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_90b38bbb47d6c5027d8d573c144e3dca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-00 |
| filingDate | 1987-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95670a92d2d521f8a703edfbffcf4b76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e237fd082dd9d21ac6a72f35e0339bae |
| publicationDate | 1990-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0351399-A1 |
| titleOfInvention | Isoquinoline derivatives, their manufacture and use |
| abstract | The present invention relates to dihydroisoquinolines and tetrahydroisoquinolines as well as to their physiologically acceptable salts, represented by the formula (I) or (I '), in which A represents -CH = or -N =, n is equal to 0 or 1, R1 and R2 are the same or different and represent H, a halogen, OH, an alkoxy of 1 to 4 carbon atoms, R3 represents H when R1 and R2 represent H, or a halogen or an alkyl group of 1 with 6 carbon atoms, R4 represents a halogen, an alkyl group of 1 to 6 carbon atoms or an amino group represented by the formula (II), where R5 and R6 are identical or different and represent H or an alkyl group of 1 with 3 carbon atoms which can be substituted by a phenyl group substituted by one or two lower alkoxy and R4 can also represent H when A represents -N =. The present invention also relates to a process for preparing these isoquinoline derivatives, in which an amide represented by formula (III), where R1-R4 and A have the same meaning as in formulas (I) or (I '), is cyclized with Lewis acid. The present invention further describes the use, as therapeutic agents of compounds of formula (I) or (I ') or their physiologically acceptable derivatives or salts. |
| priorityDate | 1987-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 303.