| abstract |
Described is a process for producing a new nimmunosuppressant, "demethimmunomycin" (L-683,742) a nC-31 demethylated analog of L-683,590 under novel nfermentation conditions utilizing the microorganism, n Actinoplanacete sp. (Merck Culture Collection MA n6559) ATCC No. 53771. The macrolide immunosupnpressant is useful in preventing human host rejection nof foreign organ transplants, e.g. bone marrow and nheart transplants. |