abstract |
Described is a process for producing a new nimmunosuppressant, "demethomycin" (L-682,993) a C-31 ndemethylated analog of L-679,934 under novel nfermentation conditions utilizing the microorganism, n Actinoplanacete sp. , (Merck Culture Collection MA n6559) ATCC No. 53771. The macrolide immunosupnpressant is useful in preventing human host rejection nof foreign organ transplants, e.g. bone marrow and nheart transplants. |