| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5a95d4999542f2d9fa147bfed0e90cf |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-855
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-815 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-815 |
| filingDate |
1989-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22efb678cdfd8a06086794dc3bcfe0ab |
| publicationDate |
1989-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0346894-A2 |
| titleOfInvention |
Extraction and purification of an anticoagulant substance from the south american leech, haementeria ghilianii |
| abstract |
Applicant has isolated a Factor X a inhibiting substance from the salivary gland extract of the leech H. ghilianii . The extract is subjected to separation using both DEAE-cellulose and heparin-agarose chromatography resins eluting with an increasing salt gradient. The extract is subjected to affinity chromatography using Factor X a bound to an Affi-Gel-15 resin eluting with HEPES containing benzamidine. Reverse phase chromatography yields several purified peptides or proteins having Factor X a inhibiting activity. The properties and clinical compositions of these FX a inhibitors are described. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5858970-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5863534-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0468764-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0352903-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5824641-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0352903-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9409039-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5801017-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5783421-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5182113-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6211341-B1 |
| priorityDate |
1988-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |