| abstract |
Derivatives of 4-amino-1-trifluoromethyl tetralin of general formula (I): in which X represents an aromatic nucleus, in particular phenyl, naphthyl or thienyl, which can bear one or two substituents chosen from halo, hydroxy, C1 to C8 alkoxy or trifluoromethyl, R1 represents a hydrogen atom or a halogen, a hydroxy group, a C1 to C8 alkoxy group, occupying one of the positions 5, 6 or 7 or also a methylene-dioxy group, occupying the positions 5 and 6 or 6 and 7. R2 represents a hydrogen atom or a halogen, a hydroxy group, a C1 to C8 alkoxy group, occupying one of the other positions 5, 6 or 7, and R3 and R4 each represent an atom of hydrogen, a methyl group or a linear or branched C1 to Cn alkyl group, n being 2 or more, optionally halogenated, hydroxylated or amino, or else R3 and R4, taken together with the nitrogen atom to which they are attached form a saturated heterocycle, optionally substituted, with five or six atoms, one or two of which are he teroatoms chosen from nitrogen, oxygen or sulfur. Drug. |