http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0346235-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c275038cf36535d44a526cb28203c03d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-04 |
| filingDate | 1989-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22cd448cc00fe2412e1ac70499c0ca3c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba634a5f110a11c04ce2604717933cfd |
| publicationDate | 1989-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0346235-A1 |
| titleOfInvention | Process for preparing N-(23-vinblastinoyl) derivatives of 1-amino methyl phosphonic acid |
| abstract | The invention relates to a new process for the preparation of derivatives of formula I in which : - R₁ represents a hydrogen atom, an alkyl radical, an alkylene radical, an arylalkyl radical optionally substituted on the aromatic ring by a halogen atom, a hydroxyl radical or an alkyl or alkoxy radical, a 2-indolyl methyl radical, a imidazolyl-4 methyl radical, or an alkoxycarbonylmethyl radical, and - R₂ and R₃, which are identical or different, each represents an alkyl radical, characterized in that the vinblastinoic acid is condensed with the N, N′-carbonyldiimidazole at ambient temperature, in an anhydrous polar solvent under an inert atmosphere, then that an aminophosphonate of the following formula is reacted in the reaction medium: in which R₁, R₂ and R₃ have the same meaning as that indicated in formula I, and then, that the medium is hydrolyzed with water and that the expected compounds are extracted, using a chlorinated hydrocarbon. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5739373-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5149812-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0497065-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2672287-A1 |
| priorityDate | 1988-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.