| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5d9f3ca41550d315642580237250c5b0 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-462 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-91 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 |
| filingDate |
1989-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af76a31697204dc3e9fd968cd0fb6c62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00a8590e266361ca16e75455cb8bc9f6 |
| publicationDate |
1989-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0345466-A2 |
| titleOfInvention |
Generation of chimeric antibodies in vivo by site-specific recombination |
| abstract |
An in vivo method of maxing chimeric antibodies is disclosed. The method comprises the steps of:n a) construction of a transfection plasmid which comprises, in operable association with DNA control regions and selectable markers, a gene segment comprising a gene or gene segment for an immunoglobulin constant heavy or light chain and a gene or gene segment for another function; b) transfection of the plasmid into a recipient mammalian antibody producing cell that secretes an immunoglobulin having at least seventy (70) percent DNA sequence homology with the immunoglobulin gene or gene segment in the plasmid; c) screening for the stably transfected antibody producing cells that secrete the chimeric antibody. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7662921-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7323171-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5928643-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5914111-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5547853-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7858095-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5728677-A |
| priorityDate |
1988-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |