http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0341704-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 |
| filingDate | 1989-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d78ee32ec83aedbfd1e15aaf5d98eef2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f60073b03f91350ef6564517deee132e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_544ea86878f432201c53cc2b8acfd056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eee19cb938ae5b25843cab1ffc539564 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5dcf6262dde45278959fd0be4771505 |
| publicationDate | 1989-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0341704-A2 |
| titleOfInvention | Process for the preparation of 2',3'-dideoxycytidines |
| abstract | a) die 4-Aminogruppe von Cytidin mit einer geeigneten Schutzgruppe schützt, b) das geschützte Cytidin zum entsprechenden Bromacetatderivat bromacetyliert, c) das Bromatom und die Acetoxygruppe aus dem Bromacetat reduktiv eliminiert um das 2′,3′-Didehydroderivat zu erhalten, d) das 2′,3′-Didehydroderivat hydriert und e) aus dem so erhaltenen an der 4-Amino und 5′-Hydroxygruppe geschützten 2′,3′-Dideoxycytidin die Schutzgruppen entfernt, um 2′,3′-Dideoxycytidin zu erhalten; sowie neue in diesem Verfahren vorkommende Zwischenprodukte. The invention relates to a process for the preparation of 2 ', 3'-dideoxycytidine, characterized in that a) protects the 4-amino group of cytidine with a suitable protective group, b) the protected cytidine is bromoacetylated to the corresponding bromoacetate derivative, c) the bromine atom and the acetoxy group are reductively eliminated from the bromoacetate in order to obtain the 2 ′, 3′-didehydro derivative, d) the 2 ', 3'-didehydro derivative is hydrogenated and e) the protective groups are removed from the 2 ′, 3′-dideoxycytidine protected at the 4-amino and 5′-hydroxy group so obtained to obtain 2 ′, 3′-dideoxycytidine; as well as new intermediates occurring in this process. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9115498-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9306119-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H05194497-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9115498-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0501511-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0501511-A2 |
| priorityDate | 1988-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 154.