| abstract |
The invention relates to Δ⁴-androstene derivatives with aromatase-inhibiting activity having the formula:n wherein nR₁ = O, (αR₅,βH) or N-O-R₆; nR₂ = H, (1-12C)hydrocarbon radical, -SH, -S-(1-12C)-hydrocarbon radical or (1-12C)acyl; nR3 = O or (αR₇,βR₈); R₄ = H or (1-12C)hydrocarbon radical; nR₅ = OH, O-(1-12C)hydrocarbon radical or O-(1-12C)acyl; nR₆ = H or (1-12C)hydrocarbon radical; nR₇ = H or (1-12C)hydrocarbon radical; and nR₈ = OH, O-(1-12C)acyl or O-(1-12C)hydrocarbon radical with the proviso that R₁ is not O if R₄ is H. |