| abstract |
Monoclonal antibody produced by a method of (a) immunizing a mouse with HCMV virions; (b) fusing spleen cells from said mouse with cells from a myeloma line to produce hybridomas; (c) selecting from said hybridomas a hybridoma producing a monoclonal antibody (i) which is reactive with HCMV, but does not react with herpes simplex, adenovirus, Epstein Barr virus or Varicella virus, and wherein said monoclonal antibody is capable of neutralizing HCMV, or (ii) which is reactive with HCMV, herpes simplex and adenovirus, and which antibody is capable of neutralizing HCMV in the absence of complement; and (d) effecting clonal expansion of said hybridoma. |