| abstract |
Continuous biotechnological preparation of optical isomer S(+) of 2-(6-methoxy-2-naphthyl) propionic acid consisting in the reaction of a racemic (R,S) ester of 2-(6-methoxy-2-naphthyl) propionic acid having melting point below 50°C of formula:n wherein nR₁ = a C₂-C₁₀ alkyl, C₄-C₆ cycloalkyl, phenyl, tetrahydropyranyl , tetrahydrofuranyl radicals and -(CH₂CH₂O) n -R2 group, wherein nn = 2-15 and nR₂ = a C₁-C₄ alkyl group, nwith the Lipase obtained from Candida Cylindracea , at temperatures ranging from 20°-60°C and at a pH ranging from 5 to 8, by feeding said ester in a continuous way into a bioreactor containing said Lipase immobilized on a porous carrier selected from adsorbent resins of the polyacrylester type having a porosity ranging from 50 to 1000 Å and a granulometry ranging from 1 to 0.01 mm. |