| abstract |
The present invention includes compounds represented by the formula:n wherein n is 0 or 1; R₁, R₂, R₃, and R₄ are independently selected from hydrogen, hydroxy, amino, alkylamino, alkylsulfonylamino, loweralkyl, loweralkoxy, halo, and thioalkoxy; or R₁ and R₂ or R₂ and R₃ taken together can form a methylenedioxy or ethylenedioxy bridge; R₁₀ is independently selected from hydrogen, loweralkyl, phenyl, and substituted phenyl; R₅ is loweralkyl; R₉ is hydrogen or loweralkyl; R₆ and R₈ are hydrogen; and R₇ isn wherein m is 0, 1 or 2; X is CH₂, O, S or N-CH₃; or R₇ isn wherein s is 0, 1, or 2; Z is C or N; and R₁₁ and R₁₂ are independently selected from hydrogen, halo, hydroxy, methoxy, thiomethoxy, amino and loweralkyl, or R₁₁ and R₁₂ taken together can form a methylenedioxy or ethylenedioxy bridge; or R₇ isn wherein t is 0 or 1; and R₉ taken together form a pyrrolidine ring and then R₆ and R₈ are hydrogen and R₇ is as described above; or R₅ and R₉ taken together form a pyrrolidine ring and then R₆ is hydrogen R₇ and R₈ taken together may form a phenyl, substituted phenyl, thienyl or furyl ring; or R₅ and R₈ taken together form a pyrrolidine ring and then R₉ and R₆ are hydrogen and R₇ is phenyl, substituted phenyl, thienyl, or furyl; or R₇ and R₉ are hydrogen and R₆ is benzyl, substituted benzyl, thienylmethyl, or furylmethyl; or a pharmaceutically acceptable salt thereof. |