| abstract |
Compounds of structure (I)n and pharmaceutically acceptable acid addition salts thereof are described in which, n is 0 to 5; and X¹ to X⁵ are any accessible combination of hydrogen, halogen, C₁₋₆alkyl, C₁₋₆alkoxy, cyano, nitro, SONH₂, SO₂CH₃, SO₂CH₂F, SO₂CHF₂, SO₂CF₃, CF₃, CHO, OH, CH₂OH, CO₂H, CO₂C p H 2p+1 wherein p is 1 to 4. n These compounds are dopamine-β-hydroxylase inhibitors. Pharmaceutical compositions are described as are methods of use. Processes for the preparation of these compounds are described. |