| abstract |
The invention relates to new 11-arylsteroid compounds, having a strong antiprogestin and a weak or nonexistent antiglucocorticoid activity, to processes for preparing said compounds and also to pharmaceutical preparations which contain these derivatives as active constituent, characterized in that said steroids have the following formula:n in which nR₁ is an aryl group with a - X n ngroup as substituent, X and Y each being separately H or a (1-4 C) hydrocarbyl group or together a (2-6 C) hydrocarbyl group which forms a 3- to 7-membered ring together with the nitrogen atom; nR₂ is hydrogen, hydroxyl, an acyloxy or an alkoxy group or a saturated or unsaturated hydrocarbyl group containing 1-8 carbon atoms, which hydrocarbyl group is provided with at least one hydroxyl, oxo, azido, cyano and/or halogen group; nR₃ is a hydroxyl, an acyloxy or an alkoxy group or an acyl group optionally substituted by a hydroxyl, alkoxy, acyloxy or halogen group; or R₂ and R₃ together form a ring system, with the proviso that if R₃ is hydroxyl, R₂ is not hydrogen or hydroxyl; and nR₄ is a methyl or ethyl group; nand the α- and β-bonds are indicated by dashed (---) and wedged ( ) lines respectively. |