| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-86 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0227
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0207
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-99
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 |
| filingDate |
1988-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acb8da8b53a33f1ee8e18a3455b3ade9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf2c04a009663eceba663ce735ba5df1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2303b58a11fed4d87ef900f9fc6cb50 |
| publicationDate |
1989-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0320205-A2 |
| titleOfInvention |
Renin inhibiting dipeptides, their preparation and compositions containing them |
| abstract |
There are described new compounds of formula (1)n wherein nR¹ represents an acyl group; nX¹ represents phenylalanine or p-methoxyphenylalanine bonded N-terminally to R¹ and C-terminally to X²; nX² represents histidine or N-methylhistidine bonded N-terminally to X¹ and C-terminally to the group -NH-; nR² represents a C₄₋₆ cycloalkyl group; nR³ represents a group CHR⁶R⁷ (where R⁶ is a hydrogen atom and R⁷ is a phenyl group, or R⁶ is a methyl group and R⁷ is a hydrogen atom or a methyl or ethyl group; nX³ represents a C₂₋₆ alkylene chain optionally substituted by one or more C₁₋₄ alkyl groups; nR⁴ and R⁵, which may be the same or different, each independently represent a hydrogen atom or a C₁₋₄ alkyl group, or NR⁴R⁵ may form a 5- or 6- membered polymethylenimine ring; nand salts and solvates thereof. n The new compounds have been found to exhibit activity as renin inhinitors, combining good duration of action with significant oral potency. n Compositions containing the compounds of formula (1) and processes for preparing the compounds are also described. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6737420-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9320839-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5972990-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5952305-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9320839-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1262175-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1262175-A2 |
| priorityDate |
1987-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |