| abstract |
Novel prostaglandins of formula (IA) and (IB) are described wherein: n = 2, 3; m = 4, 5, 6, 7; p = 5, 6, 7, Y, when X = H, -NH2, represents -NH-NH2, -CH2NH2, -NRR', wherein R and R' may be the same or different, each representing: H, a linear or branched alkyl, alkenyl, alkynyl, phenyl, substituted aryl; or, taken together with the substituent X, it may constitute the hydantoin nucleus, and Z = -CN, -CH2NH2, -CH2OH, -CHO, (a), -COCH3, (b), COW, wherein R and R' have the meanings given above and W may be -OR, -NRR'. Furthermore, the instant invention also concerns the use of the novel prostaglandins as a pharmaceutical composition having antiulcer activity. |