| abstract |
This invention relates to tri- and tetra-substituted-oxetanes of the formula,n e.g. (±)-cis- and (±)-trans-2-[(4-(4-isopropylpiperazin-1-yl)phenoxy)methyl]-4-(2,4-dihatophenyl)-4-(1H-1,2,4-triazoi-1-yl)methyl]oxetane and tri- and tetra- substituted-tetrahydrofurans, e.g. (±)-cis- and (±)-trans-1-[4-[[2-(2,4-dihalophenyl)tetrahydro-2-[(1 H-azol-1-yl)methyl]-5-furanyl]methoxy]phenyl]-4-yl-1-substituted piperazine-3-one and related derivatives which exhibit antifungal and antiallergy activities, pharmaceutical composition thereof, methods of their use in treating or preventing susceptible fungal infections and allergic reactions in a host including warm-blooded animals such as humans. |