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filingDate 1988-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a04bacbf282062bd7de6983bcca5974e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f8e14363ebac27e0ce6ebf8ccc3558f
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publicationDate 1989-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0313152-A2
titleOfInvention Process for the chemical immobilization of biologically active substances on silica
abstract A process is disclosed for the chemical immobilization of biologically active substances having a proteinic structure on SiO₂ supports, which comprises preparing a support of SiO₂ functionalised with organic silanes complying with the following general formulan wherein: nR₁ and R₂, either equal to, or different from, each other, are Cl, Br, CH₃, NO₂, H or NH₂, nR II , R III and R IV , either equal to, or different from, one another, are alkyl or alkoxy groups containing from 1 to 10 carbon atoms, nR I is equal to (CH₂) p -X-(CH₂) q , nwherein nX is CH₂ or a mono- or poly-condensed aromatic group, or NH or O, np and q, either equal to, or different from, each other, are integers which can have values comprised within the range of from 0 to 10, with the value of 0 being excluded when X is either NH or O, nand coupling the silica functionalised with the organic silane with a biologically active substance having a proteinic structure, after previously preparing a diazo salt on such a functionalised silica.
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priorityDate 1987-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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