http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0312906-A3
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-42 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-0091 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-20 |
| filingDate | 1988-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1990-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0312906-A3 |
| titleOfInvention | Novel sulfonamide derivatives |
| abstract | A sulfonamide derivative of the general formula: n nwherein, R¹ represents n(i) COOR¹¹, n(ii) CH₂OR¹² or n(iii) CONR¹³R¹⁴, nwherein nR¹¹ represents a hydrogen atom, alkyl group of nfrom 1 to 20 carbon atom(s), carbocyclic ring nunsubstituted or substituted by an alkyl or nalkoxy group of from 1 to 4 carbon atom(s) or nhalogen atom, or steroid, nR¹² represents a hydrogen atom or COR¹⁵, nR¹³ and R¹⁴ each represent a hydrogen atom or nalkyl group of form 1 to 4 carbon atom(s) or nNR¹³R¹⁴ represents an amino acid residue or nheterocyclic ring, or nR¹⁵ represetns an alkyl group of from 1 to 4 ncarbon atom(s) or phenyl group, n n n n n n nBa represents n(i) -CH₂-CH₂-(CH₂)m- (Ba-1), n(ii) cis-CH=CH-(CH₂)m- (Ba-2), n(iii) -CH₂-O-(CH₂)m- (Ba-3), n(iV) -S-(CH₂)m- (Ba-4) or n nwherein m represetns an integer of from 1 nto 6, and the configuration of a double nbond is E, Z or EZ and a phenylene group nrepresetns and o-, m- or p-phenylene group nin the formula (Ba-5), nR 2a represents a bond or an alkylene group of from 1 to 4 ncarbon atom(s), nR 3a represents a carbocyclic or heterocyclic ring unsubstituted nor substituted by from one to three of an alkyl group of from n1 to 4 carbon atom(s), alkoxy group of from 1 to 4 carbon natom(s), hydroxy group, carboxyl group, ciano group, halogen natom or nitro group, or nR 2a represents an alkyl group of from 1 to 12 carbon atom(s) ntogether with R 3a , n n n nX b represents n(i) bond, n(ii) alkylene group of from to to 4 ncarbon atoms or n(iii) alkenylene group of from 2 to 4 ncarbon atoms (with the proviso nthat nCH=CHCH₂ n and nnCH₂CH=CHCH₂ n are exluded), nR 2b represents n(i) hydrogen atom, n(ii) halogen atom or n(iii) alkyl group of from 1 to 4 carbon natom(s), nthe configuration of a double bond between C₅ and C₆ in the ngeneral formula (B) is cis, n n n n nLc represents an alkylene group of from 1 to 4 carbon atom(s). nR 2c represents a hydrogen atom, alkyl group of from 1 to 4 ncarbon atom(s) or halogen atom, nthe configuration of a double bond between C₅ and C₆ in the ngeneral formula (c) is cis or trans, nwith the proviso that when n nrepresents the general formula (A), nR¹¹ doesn't reprsents a hydrogen atom or alkyl group of from 1 to 20 ncarbon atom(s); ncyclodextrin clathrates thereof, or non-toxic salts thereof in case that nR¹¹ represents a hydrogen atom or NR¹³R¹⁴ represents an amino acid nresidue, possess an antagonistic activity on TXA₂, in particular, n n ninhibit blood platelet aggregation and contraction of artery, and are, ntherefore, useful for prevention and/or treatment of inflammation, nhypertension, thrombus, cerebral apoplexy, asthma, cardiac infarction, nangina pectoris, cerebral infarction and death by aucte cardiac diseases nin mammales, in particular in humans, which are induced by thromboxane nA₂. |
| priorityDate | 1987-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.