| abstract |
A compound for use in lowering blood cholesterol having the relative stereochemical formula:-n wherein R is hydrogen, (C₁-C₃)alkyl, phenyl, benzyl or a conventional radical forming an ester group which is hydrolyzable under physiological conditions; nR¹ and R², when taken separately, and R₃ are each independently hydrogen, (C₁-C₃)alkyl, benzyl, naphthyl, phenyl or phenyl mono or disubstituted with the same or different substituents selected from the group consisting of F, Cl, Br, I, (C₁-C₃)alkyl, CF₃, (C₁-C₃)alkoxy, benzyl and phenyl; with the proviso that at least one of R¹ and R² is other than hydrogen or (C₁-C₃)alkyl; and nR¹ and R², when taken together, are combined with the double bonded carbon atom which they are attached to form a diradical ylidene group of the formulan wherein n is 0 or 1 and Y is oxygen, OCH₂, sulfur, SCH₂, methylene or ethylene; or na pharmaceutically acceptable cationic salt thereof when R is hydrogen. |