http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0311694-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d75d1a4caed60a9316608ed9c231546c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 |
| filingDate | 1988-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1995-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e25935e4dd1be6850719f04859a06ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e0afe0ec3f197d573f42674bfea0ca6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26dcbe6a5956e42abbf1dd665ac2857c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a84bce68ba3f474a20301f52b8026f07 |
| publicationDate | 1995-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0311694-B1 |
| titleOfInvention | Nucleoside derivatives and process for their preparation |
| abstract | Dideoxynucleoside derivatives effective as antiviral agents, intermediates for their synthesis, and process for their synthesis are disclosed. The process is characterized in that a mesyl, tosyl or trifluoromethanesulfonyl group is introduced selectively into the 3'-position of a ribose unit of various nucleoside whose base and 2'- and 5'-positions of the ribose unit are protected, and the product is treated with a base and a reducing agent to give an intermediate useful for synthesizing the dinucleoside derivatives. This process enables preparation of various novel intermediates and dideoxynucleoside derivatives. Another process of synthesizing intermediates useful for synthesizing dideoxynucleoside derivatives is also disclosed, which comprises reacting a nucleoside derivative whose base and 2'- and 5'-positions of the ribose unit are protected by pivaloyl groups and 3'-position is protected by a mesyl, tosyl or trifluoromethanesulfonyl group with an alkaline compound to thereby selectively eliminate pivaloyl groups of the base. |
| priorityDate | 1987-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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