| abstract |
In these new dosage forms, the corticosteroid is contained, in strictly controlled and reproducible quantities, in solid supports intended for a progressive release of the active principle by sublingual peret.n n n Luckily, the corticosteroid is methyl prednisolone.n n n Their preparation process includes the following main steps: - dissolving the corticosteroid in a solvent, - preparation of dilutions at different concentrations, - splitting of each of these dilutions into under-dilutions, - impregnation by multi-impregnation or fractional impregnation of a solid pharmaceutically acceptable support with each of the sub-dilutions, each of said impregnation steps being followed by drying in forced air and dried at a temperature less than or equal to 35 ° C. . |