Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75fcfb61e8c9c1c77d86ee7363827081 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S424-809 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39591 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6857 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-563 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-435 |
filingDate |
1988-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5541badd434f6958cde23ffed974808e |
publicationDate |
1989-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
EP-0307754-A2 |
titleOfInvention |
Method for obtaining a papain-free antibody fragment preparation |
abstract |
A method for obtaining a papain-free F(ab′)₂ antibody fragment preparation derived from papain digested whole IgG antibody employing an antibody to papain for binding to and removing papain-associated digestion products from the preparation. The method is particularly useful for digesting whole IgG antibodies which are otherwise sensitive to pepsin digestion to provide F(ab′)₂ antibody fragments from which Fab′ antibody fragments can be obtained having available free sulfhydryl groups in the hinge region. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0464554-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0464554-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6274325-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8304195-B2 |
priorityDate |
1987-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |