| abstract |
The invention relates to enkephalin analogs of the formulan wherein in case of X isn D-Val, D-Phe, Pro, D-Met, D-Met(O), D-Leu, D-Glu, D-Glu(OBzl), D-Lys, D-Lys(Z), or D-Arg, Y is Gly or Phe; and R isn a) a direct bond, b) an alkylene group having from 1 to 6 carbon atoms. c) o-. m-. or p-phenylene group. d) a cycloalkane; or nwherein in case of X is D-Ala, Y is Phe: and R isn a) a direct bond, b) an alkylene group having from 1 to 6 carbon atoms, c) o-. m-. or p-phenylene group. or d) a cycloalkane, nits salts and hydrates, as well as a therapeutic composition containing at least one of the enkephalin analogs, as an effective component. |