| abstract |
For the production of sodium purines, in particular disodium-2-amino-1,9-dihydro-purin-6-one and sodium 1,3-dihydro-7H-purine-2,6-dione, in a "one-pot process" in technical On a scale and in high purity and high yields, a suspension consisting of the corresponding 4-amino-pyrimidine derivative and sodium nitrite in formamide is mixed with formic acid, then reduced, and the 4-amino-5-formylamino-pyrimidine derivative formed is then reduced to 140 ° to 180 ° C. heated and after the ring closure reaction is carried out by adding sodium hydroxide solution into the corresponding sodium or disodium salt, which is separated off as crystals. |