| abstract |
Compounds of the formula:n wherein, R is selected from hydrogen, loweralkyl, trifluoromethyl, carboxyl, or loweralkoxycarbonyl; R₁ and R₂ are hydrogen or loweralkyl; Z is trifluoromethyl or halogen; the optical isomers and pharmaceutically acceptable salts thereof are active as antiemetics. Two of the preferred compounds are fenfluramine and norfenfluramine. |