| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d881968fbe08047e369e84a0ec25e65b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1217
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-095 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
1988-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1995-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae80d381c4770a702d4ded7cf62c51a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_787c2de5c4660b3d7c7965d0cf97f214
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81cdbcb13ac0ee785ce319bdfe10825b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95d2ba38e4f041f61ba057239d70ccad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d4b3dabf7e558065bb31f74b214ab353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_351facf7d1d306653ad2e78b59d360a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_338c44dfaf1ed74501304301c5b563c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64057169df80e05df1b4057e2acc7a85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4167213b0e7b21f82df6bd69c125b84e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f759cb5f52d034b69d0e0be03c4c3cc |
| publicationDate |
1995-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0301992-B1 |
| titleOfInvention |
Vaccine against group B Neisseria meningitidis, gammaglobulin and transfer factor |
| abstract |
A method is provided for obtaining a vaccine against the different pathogenic serotypes of group B Neisseria meningitidis characterized by starting from live microorganisms of any one of the known pathogenic serotypes of the B group without inactivation, from which the extractation of the vesicles of the outer membrane and the protein antigenic complex of 65 - 95 KD molecular weight is carried out using detergent, enzyme and ultrasound combined in the treatment. The resulting product, after treatment to eliminate the nucleic acids, is purified by a dissociating treatment with detergent, ultrasonic bath and column chromatography. The multi-antigenic material so obtained is purified to obtain the protein antigenic complex of 65 - 95 KD molecular weight for HPLC chromatography (TSK 3000 SWG column) or affinity chromatography with monoclonal antibodies, or hydrophobicity chromatography, or ionic exchange chromatography or a combination of any one of them. The protein antigenic complex is then added to the fraction that contains the vesicles by ultrasound treatment so that it will be anchored on then, in a proportion of 15 por cent +/- 3. The capsulr polysaccharide is also added, in a proportion of 1.1 - 1.4 with respect to the protein and the adjuvant in a relation ranging from 2 - 100 mcg/protein mcg. The different components ot the mixture may be sterilized by cobalt 60 inonizing radiations with doses from 5 - 25 Kgy and a temperature between 1 - 4 grade C before preparing the mixture or the resulting mixture may be sterilized by this procedure. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0854729-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0854729-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6821521-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7786286-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7833717-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7749499-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7776335-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7273611-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1307224-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10967045-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2132383-C1 |
| priorityDate |
1987-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |