http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0300784-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac40ffdd0f9b7563bab9d5dccaa8a6b3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64 |
| filingDate | 1988-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a3fcb5f3bec38b7602cbc765ffe9d58 |
| publicationDate | 1989-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0300784-A2 |
| titleOfInvention | Peptides |
| abstract | Acyclic undecapeptides which correspond to a cyclosporin cleaved between positions 1 and 11, or such undecapeptides in which one or more of the terminal amino or methylamino and carboxy groups is in derivative form are of therapeutic value in various contexts in which the cyclosporins are used, for example as anti-bacterial agents and particularly as immunosuppressive and anti-inflammatory agents. A particular group of such undecapeptides has the formula (I) n H-A₁-A₂-A₃-A₄-A₅-A₆-A₇-A₈-A₉-A₁₀-A₁₁-OH (I) nin which A1 is either derived from 2-carboxyazetidine, 2-carboxypyrrolidine or 2-carboxypiperidine, which may optionally be substituted on a ring carbon atom other than that at position 2 by an amino, methylamino, mercapto or hydroxy group and/or by an acyclic aliphatic hydrocarbon group, or is an amino acid residuen wherein n is 0, 1 or 2, X represents an amino, methylamino, mercapto or hydroxy group, R represents hydrogen or an acyclic aliphatic hydrocarbon group and R′ represents hydrogen or a methyl group; A2 is an amino acid residue n n-NH- -CO- wherein R₁ is an acyclic aliphatic hydrocarbon group, for example of 1 to 6 carbon atoms, optionally substituted at the C₁ position of the group R₁ by an amino, methylamino, mercapto or hydroxy group; A₃ is a sarcosine residue; A₄ is an N-methyl-leucine residue; A₅ is a valine residue; A₆ is an N-methyl-leucine residue; A₇ is a alanine residue; A₈ is an alanine residue; A₉ is an N-methyl-leucine residue; A₁₀ is an N-methyl-leucine or sarcosine residue; and A₁₁ is an N-methylvaline residue; or such an acyclic undecapeptide in which one or more of the terminal amino or methylamino and carboxy groups and any amino, methylamino, mercapto or hydroxy group present in A₁ or A₂ is in derivative form. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8481483-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8349312-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8623814-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8367053-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8367618-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8685917-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0414632-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9221878-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9669095-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9387230-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8906853-B2 |
| priorityDate | 1987-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 204.