| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ba090c867801ab7bccb082f1b694ad25 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 |
| filingDate |
1988-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39076145ae66853d2d2af7e191e18782 |
| publicationDate |
1989-01-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0300725-A1 |
| titleOfInvention |
Tetrahydroisoquinolin-2-yl derivatives as thromboxane A2 antagonists |
| abstract |
The invention provides compounds of the formula (I):n and salts thereof; wherein nA is a group NR³SO₂ or SO₂NR³; nR a is an acyclic hydrocarbon group having from 1 to 4 linear carbon atoms; nR b is a bond or an acyclic hydrocarbon group having from 1 to 3 linear carbon atoms, provided that the total number of linear carbon atoms in R a and R b taken together does not exceed four and that the carbon atom in R a which is adjacent to the isoquinoline ring nitrogen atom is saturated; nthe groupn is a monocyclic group having between three and seven ring members and containing up to three heteroatoms; nY is CO₂H or a group hydrolysable to CO₂H; nR¹ is phenyl optionally substituted by one or more substituents chosen from the group comprising halogen, C₁₋₄alkyl, C₁₋₆acyl, C₁₋₄alkoxy, nitro and trifluoromethyl; nR² is hydrogen or one or more C₁₋₄alkyl substituents located at the 1, 3 and 4 positions of the isoquinoline ring; and nR³ is hydrogen or C₁₋₆alkyl. nAlso provided are compositions containing the compounds of the formula (I), a process for their preparation and their use as thromboxane A₂ antagonists. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8748615-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7229986-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8779145-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0187834-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0107412-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7504392-B2 |
| priorityDate |
1987-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |