| abstract |
Hydrocinnamic acid derivatives of the general formula wherein - from the symbols R¹ to R⁴ one or two halogen or methoxy and the rest of hydrogen; - R⁵ is hydrogen or phenyl; - R⁶ is a radical of the formula -OR¹² (a) or -NR¹³R¹⁴ (b); - R⁷ (C₁-C₄) alkyl, (C₂-C₅) alkanoylamino (C₂-C₅) alkyl, amino or (C₁-C₄) alkoxyphenyl; - R⁸ and R⁹ are each hydrogen or (C₁-C₄) alkyl; - R¹⁰ hydrogen and R¹¹ hydroxy or R¹⁰ and R¹¹ together oxo; - R¹² is hydrogen, (C₁-C₁₀) alkyl, pyridylmethyl or carbamoylmethyl; - R¹³ hydrogen, (C₁-C₄) alkyl and R¹⁴ hydrogen, (C₁-C₄) alkyl, pyridyl, phenyl- (C₁-C₄) alkyl, carboxy- (C₁-C₄) alkyl, carbamoyl- (C₁- C₄) alkyl, (C₁-C₄) alkoxycarbonyl- (C₁-C₄) alkyl, di- (C₁-C₄) alkoxycarbonyl- (C₂-C₅) alkyl, piperidino- (C₂-C₄) alkyl or halopyridinecarboxamido- (C₂-C₄ ) -alkyl or R¹³ and R¹⁴ together with the nitrogen atom denote 4- (C₁-C₄) alkyl-piperazin-1-yl, and pharmaceutically acceptable salts of basic compounds of the formula I with acids or of acidic compounds of the formula I with bases are suitable for combating or preventing cerebral insufficiency or for improving cognitive functions. |