http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0298385-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a09fa84c54c24536575f7f12c1f1db43 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 |
| filingDate | 1988-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_889f3d9944d47c52c99cd990e552787a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_386261047fe36fccfe926e48b348ac34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_768446eb144551e8b18303b25a3f0f44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed5c9f39dbd563a1b424eb0bcedd0b27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_419c5a74121aac1c04dafab8009dc223 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a373b27d7ced1b6e44fe9e5aedf24698 |
| publicationDate | 1989-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0298385-A2 |
| titleOfInvention | Cyctostatic anthracyclin derivatives |
| abstract | The invention relates to new cytostatically active anthracycline derivatives and conjugates of the following general formula I, which may be present as a salt of an inorganic or organic acid in which the radicals have the following meaning: A is an anthracyclinone of the general formula II or III, M is a structure of the general formula IV or V, and a and b are identical or different types of substituted or unsubstituted alkyl radicals of an aliphatic or benzyl aromatic nature or a and b form, together with the N atom, an optionally substituted heterocyclic ring, where in formulas II and III R¹ is hydrogen or a hydroxy group, R² is hydrogen or a hydroxy or a methoxy group, R³ is hydrogen or a hydroxy group, R⁴ is hydrogen or a hydroxy group, R⁵ CH₂CH₃, COCH₃ or a structure of the formula COCH₂OCOR, where R together with the carbonyl group represents the acyl function of a monobasic or an α, ω-dibasic aliphatic carboxylic acid or an amino acid, X is hydrogen, a hydroxy or a methoxycarbonyl group or a radical of the formula VI and Y is a radical of the formula VI, wherein in the formulas IV and V the radical Z is hydrogen or a methyl, hydroxyl, methoxy, acetoxy, nitro or Cyano group or a chlorine or bromine atom and where in formula V the residue P is a protein or peptide residue, an immunoglobulin or immunoglobulin residue, a monoclonal antibody or a Fab, Fab'- or F (ab ') ₂ Fragment or a hormone, lectin or growth factor residue, where P may optionally carry further anthracycline derivatives of the claimed coupled type, as well as processes for their preparation and their use in medicaments. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5093247-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0299350-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0299350-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4939158-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9216629-A1 |
| priorityDate | 1987-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 151.