| abstract |
Compounds of formula: <CHEM> in which, inter alia q is 0 to 2, R1 is (L)a-(CH2)b-(T)c-M wherein a and ca are 0 or 1, b is 3 to 14, L and T are independently O, S or CH2; and M is C1-4 alkyl, ethynyl, CF3, isopropenyl, furanyl, thienyl, cyclohexyl or optionally substituted phenyl; R2 and A are H, CF3, alkyl, alkoxy, halogen, OH, NO2, or NH2 or R1 and A are H and R2 is (L)a-(CH2)b-(T)c-M as above; y is COR3 or (CHX)n(CH2)p-Z wherein R3 is OH, NH2, aryloxy or alkoxy, n is 0 or 1, p is 0, 1 or 2; X is H, OH, alkyl, alkoxy or F, Z is COR3 or tetrazolyl; R is (CR5R6)dW, R5 and R6 are H or alkyl and W is an optionally substituted phenyl, pyridyl or pyrimidiyl group, intermediates and processes for their preparation and their use in therapy as leukotriene antagonists. |