| abstract |
Compounds of formula:n in which, inter alia q is 0 to 2, R₁ is (L) a -(CH₂) b -(T) c -B wherein a and c are 0 or 1, b is 3 to 14, L and T are independently O, S or CH₂; B is C₁₋₄ alkyl, ethynyl, CF₃, isopropenyl, furanyl, thienyl, furanyl, cyclohexyl or optionally substituted phenyl; R₂ and A are H, CF₃, C₁₋₄ alkyl, C₁₋₄ alkoxy, halogen, OH, NO₂ or NH₂ or R₁ and A are H and R₂ is (L) a -(CH₂) b -(T) c as above; y is COR₃ or (CHX) n (CH₂) p Z wherein R₃ is OH, NH₂, aryloxy or alkoxy, n is 0 or 1, p is 0, 1 and 2; X is H, OH, alkyl, alkoxy or F, Z is COR₃ or tetrazolyl; R is (CR₄R₅) m W, m is 0 to 6, R₄ and R₅ are alkyl and W is an optionally substituted heteroaryl group; intermediates and processes for their preparation and their use in therapy as leukotriene antagonists. |